HME2 Rabbit Polyclonal Antibody

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila| the 'engrailed' (en) gene plays an important role during development in segmentation| where it is required for the formation of posterior compartments. Different mutations in the mouse homologs| En1 and En2| produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.