FBXW2 Rabbit Polyclonal Antibody

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif| the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact| F-box proteins are one of the four subunits of ubiquitin protein ligases| called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats| leucine-rich repeats| or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.