FBXL4 Rabbit Polyclonal Antibody

This gene encodes a member of the F-box protein family| which are characterized by an approximately 40 amino acid motif| the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes| called SCF complexes| which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain| the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants.