N-Acetylputrescine

N-Acetylputrescine is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD) [1][2][3][4].

Product Specifications

CAS Number

[5699-41-2]

Product Name Alternative

NAP

UNSPSC

12352211

Hazard Statement

H314

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-acetylputrescine.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC(NCCCCN)=O

Molecular Formula

C6H14N2O

Molecular Weight

130.19

Precautions

H314

References & Citations

[3]Liu R, et al. Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs. Oncotarget. 2017 Jul 17;8 (51) :88575-88585.|[4]Peng K W, et al. Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson's Disease Biomarker Panel[J]. bioRxiv, 2021: 2021.07. 23.453542.|[1]Pfanzagl B, et al. N-acetylputrescine as a characteristic constituent of cyanelle peptidoglycan in glaucocystophyte algae. J Bacteriol. 1996 Dec;178 (23) :6994-7.|[2]Menashe M, et al. Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes. Biochem J. 1980 Apr 15;188 (1) :263-7.