Raf-1(Phospho Ser296) Polyclonal Antibody

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K)| which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated| the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2| which in turn phosphorylate to activate the serine/threonine specific protein kinases| ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle| apoptosis| cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.