PDGFR-beta(Phospho Tyr751) Polyclonal Antibody

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer| composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12| that fuses this gene to that of the translocation| ETV6| leukemia gene| results in chronic myeloproliferative disorder with eosinophilia.

Platelet-derived growth factor receptor beta; PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri

The antiserum was produced against synthesized peptide derived from human PDGF Receptor beta around the phosphorylation site of Tyr751. AA range:718-767