CCL22 Rabbit Polyclonal Antibody

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes| dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils| eosinophils| and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69)| MDC(5-69) and MDC(7-69) seem not be active.|online information:CCL22 entry|PTM:The N-terminal processed forms MDC(3-69)| MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.|Belongs to the intercrine beta (chemokine CC) family.|tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells| and thymus. Also found in lymph node| appendix| activated monocytes| resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis| allergic contact dermatitis skin| and psoriasis| in both the eptdermis and dermis.|