LAT(Phospho Tyr191) Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation| this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
CAS Number
9007-83-4
Synonyms
Linker for activation of T-cells family member 1; LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human LAT around the phosphorylation site of Tyr191. AA range:191-240
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
27930
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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