Caspase 4 Rabbit Polyclonal Antibody
Product Specifications
Background
Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|
CAS Number
9007-83-4
Synonyms
Caspase 4 ;p10; Cleaved-Ala290; Caspase-4; CASP-4; EC 3.4.22.57; ICE;rel-II; Protease ICH-2; Protease TX; Caspase-4 subunit 1; Caspase-4 subunit 2;
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human Caspase 4 (p10| Cleaved-Ala290)
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
41470
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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