KOR-1(Phospho Ser369) Polyclonal Antibody

Endogenous opioid peptides and opiates| like morphine| transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor| mu-type| delta-type and kappa-type| also designated MOR-1| DOR-1 and KOR-1| respectively. MOR-1 is a receptor for beta-endorphin| DOR-1 is a receptor for enkephalins| and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions| including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.