HDAC1(Phospho Ser421) Polyclonal Antibody

Histone acetylation and deacetylation| catalyzed by multisubunit complexes| play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2| it deacetylates p53 and modulates its effect on cell growth and apoptosis.