FAP-1 Polyclonal Antibody

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers| granulation tissue of healing wounds| and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development| tissue repair| and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Seprase ;EC 3.4.21.-;170 kDa melanoma membrane-bound gelatinase;Fibroblast activation protein alpha;Integral membrane serine protease; Seprase; EC 3.4.21.-; 170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Integral membrane serine protease