CRMP-2(Phospho Ser522) Polyclonal Antibody

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance| growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse| and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders| and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Dihydropyrimidinase-related protein 2; DPYSL2; CRMP2; ULIP2; Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2