CCR5 Polyclonal Antibody

This gene encodes a member of the beta chemokine receptor family| which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages| and is known to be an important co-receptor for macrophage-tropic virus| including HIV| to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2)| macrophage inflammatory protein 1 alpha (MIP-1 alpha)| macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line| suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemok