c-Myc(Phospho Ser62) Polyclonal Antibody

The protein encoded by this gene is a multifunctional| nuclear phosphoprotein that plays a role in cell cycle progression| apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations| overexpression| rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors| leukemias and lymphomas| including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream| in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas| suggesting its importance in the normal function of this gene.

Myc proto-oncogene protein; MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64