Rb Polyclonal Antibody
Product Specifications
Background
The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
CAS Number
9007-83-4
Synonyms
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human Rb.
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
106159
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
Frequently Asked Questions
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