mGluR5 Polyclonal Antibody

GRM5 encodes a member of the G-protein coupled receptor 3 protein family. Metabotropic glutamate receptor 5 is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. Metabotropic glutamate receptor 5 may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.