MDM2 Polyclonal Antibody
Product Specifications
Background
MDM2 encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
CAS Number
9007-83-4
Synonyms
MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human MDM2. AA range:151-200
Clonality
Polyclonal
Applications
IHC-p, IF, WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
55233
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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