Bub1 Polyclonal Antibody
Product Specifications
Background
BUB1 (BUB1 mitotic checkpoint serine/threonine kinase) encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in BUB1 have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
BUB1; BUB1L; Mitotic checkpoint serine/threonine-protein kinase BUB1; hBUB1; BUB1A
Host
Rabbit
Reactivity
Human;Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human BUB1. AA range:251-300
Clonality
Polyclonal
Applications
IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
122375
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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