ODN 24987

ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’[1].

Product Specifications

CAS Number

[1682661-48-8]

UNSPSC

12352208

Target

Toll-like Receptor (TLR)

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/odn-24987.html

Purity

92.42

Solubility

H2O : ≥ 20 mg/mL

Smiles

[DNA,d(P-thio)(C-C-T-G-G-C-c7G-G-G-G)]

Molecular Weight

3229.60

References & Citations

[1]Römmler F, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191 (6) :3240-53.|[2]Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10 (2) :e0116703.