Fluocinolone (Acetonide)

Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) [1][2][3][4].

Product Specifications

CAS Number

[67-73-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Glucocorticoid Receptor; Wnt

Type

Reference compound

Related Pathways

Immunology/Inflammation; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Fluocinolone-Acetonide.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)CO

Molecular Formula

C24H30F2O6

Molecular Weight

452.49

Precautions

H315, H319, H335

References & Citations

[1]http://en.wikipedia.org/wiki/Fluocinolone_acetonide|[2]Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.|[3]Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.|[4]Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39 (2) : 217-222.|[5]Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21 (3) : 128-133.|[6]Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2 (1) : 1-14.