RMC-113
RMC-113 is a PIP4K2C and PIKfyve inhibitor with the Ki vaules of 46 nM and 370 nM. RMC-113 reverses SARS-CoV-2-induced impairment of autophagic flux. RMC-113 shows antiviral activity[1].
Product Specifications
CAS Number
[2258606-34-5]
UNSPSC
12352005
Target
Autophagy; Dengue Virus; DNA/RNA Synthesis; Filovirus; PIKfyve; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rmc-113.html
Purity
99.54
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(OC)C=CC(C2=CC3=NSC(C#CC4=CC=CN=C4)=C3N=C2)=C1
Molecular Formula
C21H15N3O2S
Molecular Weight
373.43
References & Citations
[1]Karim M, et al. PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2. Preprint. bioRxiv. 2024;2024.04.15.589676. Published 2024 Apr 17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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