GB-6

GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR) . GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].

Product Specifications

CAS Number

[2413262-74-3]

UNSPSC

12352209

Target

Bombesin Receptor; Radionuclide-Drug Conjugates (RDCs)

Type

Peptides

Related Pathways

Antibody-drug Conjugate/ADC Related; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gb-6.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=CC=C(O)C=C21)C(NCCC(N[C@@H](CCC)C(NCC(N[C@@H](CC3=CNC=N3)C(N)=O)=O)=O)=O)=O)=O

Molecular Formula

C32H45N11O8

Molecular Weight

711.77

References & Citations

[1]Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95 (30) :11429-11439.