Elemicin

Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity[1][2][3][4].

Product Specifications

CAS Number

[487-11-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Influenza Virus; Stearoyl-CoA Desaturase (SCD)

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/elemicin.html

Purity

98.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CCC1=CC(OC)=C(OC)C(OC)=C1

Molecular Formula

C12H16O3

Molecular Weight

208.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10.|[2]Yi-Kun Wang, et al. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. J Agric Food Chem. 2019 Jul 24;67 (29) :8243-8252.|[3]Xiao-Nan Yang, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Oct 21;32 (10) :1965-1976.|[4]Ayodeji Oluwabunmi Oriola, et al. Essential Oils and Their Compounds as Potential Anti-Influenza Agents. Molecules. 2022 Nov 12;27 (22) :7797.