H-Phe (4-Ac) -OH

H-Phe (4-Ac) -OH (L-4-Acetylphenylalanine) is a keto-amino acid that can be converted from α-keto acids containing an acetyl group. H-Phe (4-Ac) -OH can be added to the amber position to form mutant Z-domain proteins. H-Phe (4-Ac) -OH is used as a functional amino acid in peptide modification to achieve chemical bonding between peptides and solid surfaces[1][2][3][4].

Product Specifications

CAS Number

[122555-04-8]

Product Name Alternative

L-4-Acetylphenylalanine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/h-phe-4-ac-oh.html

Purity

99.19

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(=O)C1=CC=C(C=C1)C[C@@H](C(=O)O)N

Molecular Formula

C11H13NO3

Molecular Weight

207.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Tang H, et al. Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications. J Mol Biol. 2022 Apr 30;434 (8) :167382.|[2]Volkwein W, et al. A Versatile Toolbox for the Control of Protein Levels Using Nε-Acetyl-l-lysine Dependent Amber Suppression. ACS Synth Biol. 2017 Oct 20;6 (10) :1892-1902.|[3]Liu H, Wang L, Brock A, Wong CH, Schultz PG. A method for the generation of glycoprotein mimetics. J Am Chem Soc. 2003 Feb 19;125 (7) :1702-3. |[4]Zhao Y, et al. A fluorescent amino acid probe to monitor efficiency of peptide conjugation to glass surfaces for high density microarrays. Mol Biosyst. 2012 Mar;8 (3) :879-87.