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Saikosaponin B1

Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT2C receptor with an EC50 of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) [1][4].

Product Specifications

CAS Number

58558-08-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Hedgehog; Interleukin Related; Smo; STAT; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/saikosaponin-b1.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@@]1(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)C[C@H](O)[C@@]5(CO)CCC(C)(C)CC5=C4C=C[C@]3([H])[C@@]2(C)CC[C@@H]1O[C@]6([H])O[C@H](C)[C@H](O)[C@H](O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O

Molecular Formula

C42H68O13

Molecular Weight

780.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Luo J, et al., Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway. J Nat Med. 2022 Jun;76 (3) :584-593.|[2]Shao, M., et al., (2025), Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation. Exploration 270000. |[3]Peng D, et L., Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice. Molecules. 2023 Jan 18;28 (3) :967. |[4]Sun, C. L., et al., (2017) . Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity. Chinese journal of natural medicines, 15 (6), 467–473.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor

Available Sizes

Frequently Asked Questions

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