TCO-PEG4-NHS ester
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
CAS Number
[1621096-79-4]
UNSPSC
12352005
Hazard Statement
H316, H341, H350, H371, H373, H412
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-tco-peg4-nhs-ester.html
Purity
99.16
Solubility
10 mM in DMSO
Smiles
O=C(OC1CC/C=C/CCC1)NCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Molecular Formula
C24H38N2O10
Molecular Weight
514.57
Precautions
H316, H341, H350, H371, H373, H412
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1013.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
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