Avibactam sodium salt-13C5
Product Specifications
UNSPSC Description
Avibactam sodium salt-13C5 (NXL-104-13C5) is 13C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1][2].
Target Antigen
Antibiotic; Bacterial; Beta-lactamase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/avibactam-sodium-salt-13c5.html
Smiles
O=S(ON1[13C@]2([H])[13CH2][13CH2][13C@@H]([13C](N)=O)[N@@](C2)C1=O)(O[Na])=O
Molecular Weight
292.19
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.|[3]Ehmann DE, et al.
 Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
 Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.|[4]Livermore DM, et al.
 Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104).
 J Antimicrob Chemother. 2012 Jun;67(6):1354-8.|[5]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14879S2/Avibactam-sodium-salt-13C5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14879S2/
Clinical Information
No Development Reported
Curated Selection
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