Avibactam sodium salt-13C5

Avibactam sodium salt-13C5 (NXL-104-13C5) is 13C labeled Avibactam (sodium) . Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1][2].

Product Specifications

Product Name Alternative

NXL-104-13C5

UNSPSC

12352005

Target

Antibiotic; Bacterial; Beta-lactamase; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/avibactam-sodium-salt-13c5.html

Purity

99.9

Smiles

O=S(ON1[13C@]2([H])[13CH2][13CH2][13C@@H]([13C](N)=O)[N@@](C2)C1=O)(O[Na])=O

Molecular Formula

C2 13C5H10N3NaO6S

Molecular Weight

292.19

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2299-304.|[3]Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109 (29) :11663-8.|[4]Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104) . J Antimicrob Chemother. 2012 Jun;67 (6) :1354-8.|[5]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.