CW 008
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion[1][2][3].
Product Specifications
CAS Number
1134613-19-6
UNSPSC
12352005
Target
Epigenetic Reader Domain; PKA
Type
Reference compound
Related Pathways
Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cw-008.html
Purity
98.15
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)F)NC2=NNC3=C2C=C(F)C(C4=C5C=C(OC)C=CN5N=C4)=N3
Molecular Formula
C21H14F2N6O2
Molecular Weight
420.37
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKA
Available Sizes
Frequently Asked Questions
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