Human TDP-43 Protein, His Tag
Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1) .
Product Specifications
Background
TDP-43, the transactive response (TAR) -DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE) .
Accession Number
Q13148-1
Expression Region
Met 1 - Met 414
Host
E. coli
Target
TDP-43
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Human TDP-43, His Tag (Cat. No. TD3-H5145) at 1 μg/mL (100 μL/well) can bind Anti-TDP43 Antibody with a linear range of 0.2-3 ng/mL (QC tested).
Format
Liquid
Buffer
50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0
Additives
Glycerol
Molecular Weight
46.8 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/TD3-H5145.pdf
Species
Human
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