Mca-PLAQAV-Dpa-RSSSR-NH2 (TFA)
Product Specifications
UNSPSC Description
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE): ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis[1].
Target Antigen
Fluorescent Dye; MMP
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mca-endo-1a-dap-dnp-tnf-alpha-5-to-6-amide-human-tfa.html
Purity
99.21
Solubility
H2O : 12.5 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)=O)=O)CC(C3=CC=C(OC)C=C3O4)=CC4=O.OC(C(F)(F)F)=O
Molecular Weight
1752.72
References & Citations
[1]Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017. |[2]Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5. |[3]Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6. |[4]Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3722A/Mca-PLAQAV-Dpa-RSSSR-NH2-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3722A/Mca-endo-1a-Dap-Dnp-TNF-Alpha-5-to-6-amide-human-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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