LW1564
Product Specifications
UNSPSC Description
LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].
Target Antigen
AMPK; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8
Molecular Weight
731.84
References & Citations
[1]Kim I, et al., The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation. Exp Mol Med. 2020 Nov;52(11):1845-1856.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
2668337-39-9
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