LW1564
LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].
Product Specifications
CAS Number
[2668337-39-9]
UNSPSC
12352005
Target
AMPK; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8
Molecular Formula
C42H48F3N3O5
Molecular Weight
731.84
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170027/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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