LW1564

LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].

Product Specifications

CAS Number

[2668337-39-9]

UNSPSC

12352005

Target

AMPK; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8

Molecular Formula

C42H48F3N3O5

Molecular Weight

731.84

References & Citations

[1]Kim I, et al., The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF) -1α accumulation. Exp Mol Med. 2020 Nov;52 (11) :1845-1856.