Heartland bandavirus Nucleocapsid Protein (HRTV-NP)

Heartland virus (HRTV) is a recently described tick-borne phlebovirus. Phleboviruses are single-stranded RNA viruses in the family Bunyaviridae. The original two cases of HRTV disease were initially reported in adult males from Missouri. Both case-patients presented with a non-specific febrile illness with leukopenia and thrombocytopenia and history of tick exposure. They were initially diagnosed with ehrlichiosis for which they received doxycycline. The case-patients required hospitalization for approximately 11 days before being discharged to home where they eventually recovered. Subsequent field work identified the virus in Ambylommaamericanum ticks collected on one of the original patient’s farms and at a nearby site .

Heartland virus isolate Patient1 segment S, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.