Puumala orthohantavirus Nucleocapsid Protein (PUUV-NP)

Puumala virus (PUUV) belongs to the order Bunyavirales, family Hantaviridae, genus Orthohantavirus. It was first isolated in 1979 from bank voles (Myodes glareolus) in Puumala (Finland), as a virus related to but distinct from the prototype orthohantavirus, Hantaan virus (HTNV), discovered in Korea . Hantavirus genome comprises three negative-stranded RNA segments: The large (L) segment encoding the viral RNA-dependent RNA polymerase, the medium (M) segment encoding the envelope glycoproteins Gn and Gc precursor (GPC), the small (S) segment encoding the viral nucleocapsid protein , and, for some hantaviruses, also the nonstructural protein (NSs) . PUUV is the causative agent of nephropathia epidemica (NE), a mild form of an hemorrhagic fever with renal syndrome (HFRS) transmitted by infected bank voles.

Puumala orthohantavirus Nucleocapsid Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.