Kyasanur Forest disease virus E protein ectodomain (KFDV-E)

Kyasanur Forest Disease (KFD) is a tick-borne viral hemorrhagic disease caused by the Kyasanur Forest Disease Virus (KFDV) . The virus is a member of family Flaviviridae, genus flavivirus and categorized as a bio-safety class-4 level pathogen1. KFDV was first identified and isolated from sick and dead monkeys in the forest regions of Shimoga district situated in the State of Karnataka, India and reported during the year 19572. Eventually, KFD infections were noticed among persons who visited the forests. Monkeys and humans are most susceptible to the KFDV, and the virus gets transmitted through hard ticks belonging to the genus Haemaphysalis. Since the discovery of KFDV, the disease was investigated in and around Karnataka state and it was observed that the KFDV was reported from only five districts of Karnataka namely, Shimoga, Chikkamagalore, Uttara-Kannada, Dakshina-Kannada, and Udupi4.

Kyasanur Forest disease virus E protein ectodomain, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.