Esculetin

Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF) -induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].

Product Specifications

CAS Number

[305-01-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; PI3K

Type

Natural Products

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/esculetin.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC(O)=C(O)C=C2O1

Molecular Formula

C9H6O4

Molecular Weight

178.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.|[2]Arora R, et al. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol Cancer. 2016 Oct 18;15 (1) :64. |[3]Chen Y, et al. Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells. Front Immunol. 2018 Sep 12;9:2092. |[4]Kim WK, et al. Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. Biochem Pharmacol. 2018 Jun;152:71-83.|[5]Martín-Aragón S, et al. Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:1-16.