CD229 Recombinant Protein

T lymphocyte surface antigen Ly9 (CD229), also designated lymphocyte antigen 9 or cell-surface molecule Ly9, is a cell surface glycoprotein. CDC229 is a Type I membrane protein that is crucial in adhesion reactions between T lymphocytes and accessory cells (homophilic interaction) . It belongs to the CD2 subfamily of the immunoglobulin gene superfamily of proteins (along with CD2, CD48, CD58, CD84, CD244 and CD150) . Receptors of this family are important in cytokine production regulation and cytotoxicity of lymphocytes and NK cells. CD229 interacts with the SAP/SH2D1A protein. CD229 is expressed on mature B cells, T cells, thymocytes and NK cells.

KDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVTMKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDLPYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRDTEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGPYHAYVCSEASSVTSMTHVTLLIYRRLRKPKITWSLRHSEDGICRISLTCSVEDGGNTVMYTWTPLQKEAVVSQGESHLNVSWRSSENHPNLTCTASNPVSRSSHQFLSENICSGPERNTK