CD358 Recombinant Protein

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL) . They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD) . The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases. DR6, also known as TNFRSF21, is a TNFR family member able to induce apoptosis as well as activation of NF-κB and JNK. Expression of DR6 is upregulated by NF-κB signaling. DR6 appears to play a critical role in the activation and differentiation of T and B lymphocytes. In the nervous system, β-amyloid precursor protein (APP) activates DR6 to trigger neuronal degeneration.

CAGCCTGAACAGAAAGCCAGTAATCTGATTGGTACCTATCGCCATGTTGATCGCGCCACCGGTCAGGTGCTGACCTGCGATAAATGTCCGGCAGGCACCTATGTTAGCGAACATTGTACCAATACCAGTCTGCGCGTGTGCAGTAGCTGTCCGGTTGGTACCTTCACCCGTCATGAAAATGGCATTGAAAAATGCCATGATTGTAGTCAGCCGTGTCCGTGGCCGATGATTGAAAAACTGCCGTGCGCCGCCCTGACCGATCGCGAATGTACCTGCCCGCCGGGCATGTTCCAGAGTAATGCAACCTGCGCCCCGCATACCGTGTGTCCGGTTGGCTGGGGTGTTCGTAAAAAAGGTACCGAAACCGAAGATGTGCGTTGTAAACAGTGTGCCCGCGGTACCTTCAGCGATGTGCCGAGCAGCGTTATGAAATGCAAAGCATATACCGATTGCCTGAGCCAGAATCTGGTTGTGATTAAACCGGGCACCAAAGAAACCGATAATGTGTGTGGCACCCTGCCGAGCTTCAGTAGCAGTACCAGCCCGAGTCCGGGCACCGCAATCTTCCCGCGCCCGGAACACATGGAAACACATGAAGTGCCGAGCTCAACCTATGTGCCGAAAGGTATGAATAGCACCGAAAGTAATAGCAGTGCCAGTGTTCGCCCGAAAGTTCTGAGCAGCATTCAGGAAGGCACCGTTCCGGATAATACCAGTAGTGCCCGTGGTAAAGAAGATGTTAATAAAACCTTACCGAACCTGCAGGTTGTTAATCATCAGCAGGGTCCGCATCATCGTCATATTCTGAAACTGCTGCCGAGCATGGAAGCAACCGGCGGCGAAAAAAGCAGTACCCCGATTAAAGGTCCGAAACGCGGTCATCCGCGCCAGAATCTGCATAAACACTTCGATATTAATGAGCAT