CD158d Recombinant Protein
Product Specifications
Background
NKAT (NK-associated transcripts) gene products, known as killer immunoglobulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM) . KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif) . The human inhibitory human killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), also referred to as 2DL4 or CD158d, triggers potent IFN-γ responses but weak cytotoxicity in resting NK cells because of the low stoichiometric association with γ
CAS Number
9000-83-3
Swiss Prot
Q99706
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~28kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
TGGGCACATGTTGGTGGTCAGGATAAACCGTTCTGCAGCGCATGGCCGAGCGCCGTTGTTCCGCAGGGTGGTCATGTGACCCTGCGTTGTCATTATCGTCGTGGCTTCAATATCTTCACCCTGTATAAAAAAGACGGCGTTCCGGTTCCGGAACTGTATAATCGTATCTTCTGGAATAGCTTCCTGATTAGCCCGGTGACCCCGGCCCATGCAGGCACATATCGTTGCCGCGGCTTCCATCCGCATAGCCCGACCGAATGGAGCGCACCGAGCAATCCGCTGGTGATTATGGTTACCGGCCTGTATGAAAAACCGAGTCTGACCGCCCGTCCGGGTCCGACAGTGCGTGCAGGTGAAAATGTGACCCTGAGTTGTAGCAGCCAGAGTAGCTTCGATATCTATCATCTGAGTCGTGAAGGTGAAGCCCATGAACTGCGTCTGCCGGCAGTTCCGAGCATTAATGGCACCTTCCAGGCAGACTTCCCGCTGGGTCCGGCAACCCATGGTGAAACCTATCGCTGCTTCGGTAGCTTCCATGGTAGCCCGTATGAATGGAGCGATCCGAGCGATCCGCTGCCGGTGAGCGTGACCGGTAATCCGAGTAGCAGTTGGCCGAGCCCGACCGAGCCGAGCTTCAAAACCGGCATTGCCCGCCATCTGCAT
Available Sizes
Curated Selection
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