CD151 Recombinant Protein
Product Specifications
Background
CD151 (PETA-3, SFA-1) is a member of the evolutionarily conserved tetraspanin family of multipass glycoproteins (TM4SF), highlighted by four transmembrane domains, two extracellular loops, and N/C-termini that reside within the cytoplasm. Identified as the first member of the tetraspanin family to be implicated in tumorigenesis, research studies have demonstrated that CD151 participates in tumor neovascularization, tumor cell cell invasion, and cell adhesion. Furthermore, a positive correlation exists between CD151 expression levels and poor prognosis for tumors of the lung, kidney, and prostate. CD151 is localized predominantly to the plasma membrane and research studies have demonstrated that CD151 exerts its pro-tumorigenic effects, in part, through the modulation of laminin-binding integrins and oncogenic receptor tyrosine kinases, such as c-Met and EGFR.
CAS Number
9000-83-3
Swiss Prot
P48509
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~30kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
GCTTATTACCAGCAGCTGAATACCGAACTGAAAGAAAATCTGAAAGATACCATGACCAAACGTTATCATCAGCCGGGCCATGAAGCCGTTACCAGCGCCGTTGATCAGCTGCAGCAGGAATTCCATTGCTGCGGTAGTAATAATAGTCAGGATTGGCGCGATAGCGAATGGATTCGTAGTCAGGAAGCCGGTGGTCGCGTGGTGCCGGATAGCTGTTGTAAAACCGTTGTGGCCCTGTGTGGCCAGCGCGATCATGCCAGCAATATCTATAAAGTGGAAGGCGGTTGCATTACCAAACTGGAAACCTTCATTCAGGAACATCTGCGC
Available Sizes
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