CD50/ICAM-3 Recombinant Protein
Product Specifications
Background
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth. These proteins are thought to play an important role in embryogenesis and development. ICAM-3, also designated CD50 and ICAM-R, is a type I membrane protein that is thought to regulate morphological changes during cell locomotion. ICAM-3 acts as a counter-receptor for the leukocyte Integrin αL/β2, and is known to activate T cells and polymorphonuclear leukocytes. ICAM-3 also binds to Moesin, via the cytoplasmic domain of ICAM-3. The expression of ICAM-3 is induced by RANTES, a chemoattractant known to activate T lymphocytes. ICAM-3 is also a major ligand for the leukocyte Integrin LFA-1 (CD11a/CD18) .
CAS Number
9000-83-3
Swiss Prot
P32942
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~50kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
CAGGAATTCCTGCTGCGCGTGGAACCGCAGAATCCGGTTCTGAGTGCCGGCGGTAGTCTGTTCGTTAATTGCAGTACCGATTGTCCGAGCAGTGAAAAAATTGCACTGGAAACCAGCCTGAGCAAAGAACTGGTTGCCAGCGGCATGGGTTGGGCAGCATTCAATCTGAGCAATGTGACCGGCAATAGTCGTATTCTGTGTAGCGTGTATTGTAATGGTAGTCAGATTACCGGCAGTAGCAATATTACCGTGTATCGTCTGCCGGAACGCGTGGAACTGGCCCCGCTGCCTCCGTGGCAGCCTGTTGGTCAGAACTTCACCCTGCGTTGCCAGGTGGAAGATGGCAGCCCGCGTACCAGTCTGACCGTGGTGCTGCTGCGCTGGGAAGAAGAACTGAGTCGTCAGCCGGCAGTTGAAGAACCGGCAGAAGTGACCGCCACCGTGCTGGCAAGTCGTGATGATCATGGCGCCCCGTTCAGTTGCCGTACCGAACTGGATATGCAGCCGCAGGGTCTGGGTCTGTTCGTTAACACCAGTGCACCGCGTCAGCTGCGTACCTTCGTTCTGCCGGTGACCCCGCCGCGCCTGGTTGCACCTCGCTTCCTGGAAGTTGAAACCAGTTGGCCGGTGGATTGCACCCTGGATGGCCTGTTCCCGGCCAGTGAAGCCCAGGTGTATCTGGCACTGGGTGATCAGATGCTGAATGCCACCGTTATGAATCATGGCGATACCCTGACCGCCACCGCAACCGCAACCGCGCGTGCAGATCAGGAAGGTGCACGCGAAATTGTGTGTAATGTGACCCTGGGCGGCGAACGTCGCGAAGCACGCGAAAATCTGACCGTGTTCAGCTTCCTGGGTCCGATTGTGAATCTGAGCGAACCGACCGCACATGAAGGCAGCACCGTGACCGTGAGTTGCATGGCAGGCGCACGCGTGCAGGTGACCCTGGATGGTGTGCCGGCCGCCGCACCTGGTCAGCCTGCACAACTGCAGCTGAATGCAACCGAAAGCGATGATGGTCGTAGCTTCTTCTGCAGCGCAACCCTGGAAGTTGATGGCGAATTCCTGCATCGTAATAGTAGCGTTCAGCTGCGTGTGCTGTATGGTCCGAAAATTGATCGTGCAACCTGTCCGCAGCATCTGAAATGGAAAGATAAAACCAGACATGTTCTGCAGTGTCAGGCACGTGGTAATCCGTATCCGGAACTGCGTTGTCTGAAAGAAGGTAGTAGTCGCGAAGTTCCGGTTGGTATTCCGTTCTTCGTTAATGTGACCCATAATGGCACCTATCAGTGTCAGGCCAGCAGTAGCCGCGGCAAATATACCCTGGTGGTGGTGATGGATATTGAAGCAGGCAGCAGTCAT
Available Sizes
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