CD31 Recombinant Protein
Product Specifications
Background
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.
CAS Number
9000-83-3
Swiss Prot
P16284
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~63kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
CAGGAAAATAGCTTCACCATTAATAGTGTTGATATGAAAAGCCTGCCGGATTGGACCGTTCAGAATGGTAAAAATCTGACCCTGCAGTGCTTCGCAGATGTGAGTACCACCAGTCATGTGAAACCGCAGCATCAGATGCTGTTCTATAAAGATGATGTTCTGTTCTATAACATCAGTAGTATGAAAAGTACCGAAAGCTACTTCATTCCGGAAGTGCGTATCTATGATAGTGGTACCTATAAATGCACCGTGATTGTTAATAATAAGGAAAAAACCACCGCCGAATATCAGGTGCTGGTGGAAGGTGTGCCGAGCCCGCGCGTTACCCTGGATAAAAAAGAAGCAATTCAGGGTGGTATTGTTCGCGTGAATTGCAGCGTGCCGGAAGAAAAAGCACCGATTCACTTCACCATTGAAAAACTGGAACTGAATGAAAAAATGGTTAAGCTGAAACGCGAAAAAAATAGTCGCGATCAGAACTTCGTTATTCTGGAATTCCCGGTGGAAGAACAGGATCGTGTTCTGAGCTTCCGCTGTCAGGCCCGCATTATTAGTGGCATTCACATGCAGACCAGCGAAAGCACCAAAAGTGAACTGGTTACCGTGACCGAAAGCTTCAGTACCCCGAAATTCCATATTAGTCCGACCGGCATGATTATGGAAGGCGCACAGCTGCATATTAAATGTACCATTCAGGTTACCCATCTGGCCCAGGAATTCCCGGAAATTATTATTCAGAAAGATAAGGCCATCGTTGCACATAATCGTCATGGTAATAAAGCCGTGTATAGTGTTATGGCCATGGTTGAACATAGTGGTAATTATACCTGTAAAGTGGAAAGTAGCCGTATTAGCAAAGTTAGTAGTATTGTTGTTAACATCACCGAACTGTTCAGTAAACCGGAACTGGAAAGTAGCTTCACCCATCTGGATCAGGGCGAACGTCTGAATCTGAGTTGCAGTATTCCGGGTGCACCGCCGGCCAACTTCACCATTCAGAAAGAAGATACCATTGTGAGTCAGACCCAGGACTTCACCAAAATTGCAAGTAAAAGCGATAGTGGCACCTATATCTGTACCGCCGGCATTGATAAAGTTGTTAAAAAAAGCAACACCGTTCAGATTGTTGTGTGTGAAATGCTGAGTCAGCCGCGCATTAGCTATGATGCACAGTTCGAAGTTATTAAAGGCCAGACCATTGAAGTTCGCTGTGAAAGTATTAGCGGCACCCTGCCGATTAGTTATCAGCTGCTGAAAACCAGTAAAGTGCTGGAAAATAGCACCAAAAATAGCAATGATCCGGCAGTGTTCAAAGATAATCCGACCGAAGATGTGGAATATCAGTGCGTTGCAGATAATTGTCATAGCCATGCCAAAATGCTGAGCGAAGTTCTGCGTGTTAAAGTGATTGCACCGGTGGATGAAGTGCAGATTAGCATTCTGAGCAGCAAAGTGGTGGAAAGCGGTGAAGATATTGTGCTGCAGTGTGCCGTTAATGAAGGCAGTGGTCCGATTACCTATAAATTCTATCGTGAAAAAGAGGGTAAGCCGTTCTATCAGATGACCAGTAATGCCACCCAGGCCTTCTGGACCAAACAGAAAGCAAGTAAAGAACAGGAAGGTGAATATTATTGTACCGCCTTCAATCGCGCCAATCATGCAAGCAGTGTTCCGCGTAGTAAAATTCTGACCGTTCGTGTGATTCTGGCCCCGTGGAAAAAA
Available Sizes
Curated Selection
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