CD180 Recombinant Protein

Product Specifications

Background

CD180/RP105 is a type-I transmembrane glycoprotein that is restricted to expression in mature B-cells. Research studies have shown that CD180 engages signaling cascades in mature B-cells that drive cell proliferation. Indeed, CD180 functions with TLR4 as an LPS receptor on B-cells and, upon binding LPS, transmits proliferation and survival signals that require the Vav family of guanine nucleotide exchange factors.

CAS Number

9000-83-3

Swiss Prot

Q99467

Modification Site

NdeI-XhoI

Expression System

Pet-22b (+)

Tag

His-tag

Purity

Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .

Solubility

PBS, 4M Urea, PH7.4

Molecular Weight

~66kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Host or Source

E.coli

AA Sequence

TGGGATCAGATGTGCATTGAAAAAGAAGCCAATAAAACCTATAACTGTGAAAATCTGGGCCTGAGTGAAATTCCGGATACCCTGCCGAATACCACCGAATTCCTGGAATTCAGCTTCAACTTCCTGCCGACCATTCATAATCGCACCTTCAGCCGCCTGATGAATCTGACCTTCCTGGATCTGACCCGCTGTCAGATTAATTGGATTCATGAAGATACCTTCCAGAGCCATCATCAGCTGAGCACCCTGGTTCTGACCGGTAATCCGCTGATCTTCATGGCCGAAACCAGTCTGAATGGTCCGAAAAGCCTGAAACATCTGTTCCTGATTCAGACCGGTATTAGCAATCTGGAATTCATTCCGGTGCATAATCTGGAAAATCTGGAAAGCCTGTATCTGGGCAGTAATCATATTAGTAGCATTAAATTCCCGAAGGACTTCCCGGCCCGTAATCTGAAAGTTCTGGACTTCCAGAATAATGCAATTCATTATATCAGCCGCGAAGATATGCGTAGTCTGGAACAGGCAATTAATCTGAGCCTGAACTTCAATGGCAATAATGTGAAAGGCATTGAACTGGGTGCCTTCGATAGTACCATCTTCCAGAGTCTGAACTTCGGTGGTACCCCGAATCTGAGCGTTATCTTCAATGGTCTGCAGAATAGCACCACCCAGAGCCTGTGGCTGGGCACCTTCGAAGATATTGATGATGAAGATATTAGCAGTGCCATGCTGAAAGGTCTGTGCGAAATGAGCGTTGAAAGTCTGAATCTGCAGGAACATCGCTTCAGTGATATTAGCTCAACCACCTTCCAGTGCTTCACCCAGCTGCAGGAACTGGATCTGACAGCAACCCATCTGAAAGGCCTGCCGAGTGGCATGAAAGGCCTGAATCTGCTGAAAAAACTGGTGCTGAGCGTTAATCACTTCGATCAGCTGTGCCAGATTAGCGCAGCAAACTTCCCGAGCCTGACCCATCTGTATATTCGCGGTAATGTGAAAAAACTGCATCTGGGCGTTGGTTGTCTGGAAAAACTGGGTAATCTGCAGACCCTGGATCTGAGCCATAATGATATTGAAGCAAGCGATTGTTGTAGCCTGCAGCTGAAAAATCTGAGCCATCTGCAGACCTTAAATCTGAGTCATAATGAACCGCTGGGTCTGCAGAGTCAGGCATTCAAAGAATGTCCGCAGCTGGAACTGCTGGATCTGGCCTTCACCCGCCTGCATATTAATGCACCGCAGAGCCCGTTCCAGAATCTGCACTTCCTGCAGGTGCTGAATCTGACCTATTGCTTCCTGGATACCAGCAATCAGCATCTGCTGGCCGGCCTGCCGGTTCTGCGTCATCTGAATCTGAAAGGCAATCACTTCCAGGATGGTACCATTACCAAAACCAATCTGCTGCAGACCGTGGGCAGCCTGGAAGTGCTGATTCTGAGCAGCTGCGGCCTGCTGAGTATTGATCAGCAGGCCTTCCATAGCCTGGGCAAAATGAGTCATGTTGATCTGAGCCACAATAGCCTGACCTGTGATAGCATTGATAGCCTGAGCCATCTTAAAGGTATCTATCTGAATCTGGCCGCCAATAGTATTAATATTATTAGCCCGCGTCTGCTGCCGATTCTGAGTCAGCAGAGCACCATTAATCTGTCACATAATCCGCTGGATTGCACCTGCAGTAATATTCACTTCCTGACCTGGTATAAAGAAAATCTGCATAAACTGGAAGGTAGCGAAGAAACCACCTGTGCAAATCCGCCGAGCCTGCGCGGTGTTAAACTGAGCGATGTTAAACTGAGTTGTGGC