CD109 Recombinant Protein
Product Specifications
Background
CD109 is a glycosylphosphatidylinositol (GPI) -linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers.
CAS Number
9000-83-3
Swiss Prot
Q6YHK3
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~36kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
CTGAGCAGTGTGGGCAGCCCGAAAGCAAAAGAAGCACTGAATATGCTGACCTGGCGCGCAGAACAGGAAGGTGGCATGCAGTTCTGGGTGAGCAGTGAAAGCAAACTGAGCGATAGTTGGCAGCCGCGTAGCCTGGATATTGAAGTTGCAGCCTATGCACTGCTGAGTCACTTCCTGCAGTTCCAGACCAGCGAAGGTATTCCGATTATGCGTTGGCTGAGCCGTCAGCGCAATAGTCTGGGCGGCTTCGCAAGTACCCAGGATACCACCGTGGCCCTGAAAGCCCTGAGCGAATTCGCAGCACTGATGAATACCGAACGCACCAATATTCAGGTTACCGTGACCGGCCCGAGTAGCCCGAGCCCTGTGAAATTCCTGATTGATACCCATAATCGTCTGCTGCTGCAGACCGCAGAACTGGCAGTTGTGCAGCCGACCGCCGTTAATATTAGTGCCAATGGCTTCGGCTTCGCAATCTGTCAGCTGAATGTGGTGTATAATGTGAAAGCCAGTGGTAGCAGCCGCCGCCGCCGCAGCATTCAGAATCAGGAAGCATTCGATCTGGATGTGGCCGTTAAAGAAAATAAAGATGATCTGAATCACGTGGATCTGAATGTGTGTACCAGCTTCAGTGGCCCGGGTCGCAGTGGCATGGCACTGATGGAAGTTAATCTGCTGAGCGGCTTCATGGTTCCGAGTGAAGCAATTAGTCTGAGCGAAACCGTGAAAAAAGTTGAATATGATCATGGTAAGCTGAATCTGTATCTGGATAGTGTTAATGAAACACAATTCTGTGTGAATATCCCGGCAGTGCGTAACTTCAAAGTTAGCAATACCCAGGATGCAAGCGTTAGCATTGTGGATTATTATGAACCGCGCCGTCAGGCCGTGCGTAGCTATAATAGCGAAGTGAAACTGAGTAGTTGTGATCTGTGCAGTGATGTGCAGGGTTGTCGTCCGTGCGAAGATGGTGCA
Available Sizes
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