CD105 Recombinant Protein
Product Specifications
Background
CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
CAS Number
9000-83-3
Swiss Prot
P17813
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~62kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
GAAACCGTGCATTGCGATCTGCAGCCGGTTGGTCCGGAACGCGGTGAAGTTACCTATACCACCAGCCAGGTTAGTAAAGGCTGTGTTGCACAGGCACCGAATGCCATTCTGGAAGTGCATGTTCTGTTCCTGGAATTCCCGACCGGTCCGAGTCAGCTGGAACTGACCCTGCAGGCCAGCAAACAGAATGGCACCTGGCCGCGCGAAGTTCTGCTGGTTCTGAGTGTTAATAGCAGCGTGTTCCTGCATCTGCAGGCCCTGGGCATTCCGCTGCATCTGGCATATAATAGTAGTCTGGTTACCTTCCAGGAACCGCCGGGTGTTAATACCACCGAACTGCCGAGCTTCCCGAAAACACAAATTCTGGAATGGGCAGCCGAACGTGGCCCGATTACCAGCGCCGCAGAACTGAATGATCCGCAGAGCATTCTGCTGCGCCTGGGCCAGGCCCAGGGCAGCTTAAGCTTCTGCATGCTGGAAGCAAGTCAGGATATGGGTCGCACCCTGGAATGGCGCCCGCGCACACCTGCACTGGTGCGTGGTTGCCATCTGGAAGGTGTTGCCGGCCATAAAGAAGCACATATTCTGCGCGTGCTGCCGGGTCATAGCGCAGGCCCTCGCACCGTTACCGTGAAAGTTGAACTGAGTTGTGCACCGGGTGATCTGGATGCCGTTCTGATTCTGCAGGGTCCGCCGTATGTGAGTTGGCTGATTGATGCAAATCATAATATGCAGATCTGGACCACCGGTGAATATAGCTTCAAAATCTTCCCGGAAAAAAATATTCGTGGCTTCAAACTGCCGGATACCCCGCAGGGTCTGCTGGGTGAAGCCCGTATGCTGAATGCAAGCATTGTTGCAAGCTTCGTTGAACTGCCGCTGGCAAGCATTGTGAGTCTGCATGCAAGCAGCTGCGGTGGTCGTCTGCAGACCAGCCCGGCCCCTATTCAGACCACCCCGCCGAAAGATACCTGCAGTCCGGAACTGCTGATGAGCCTGATTCAGACCAAATGTGCAGATGATGCCATGACCCTGGTTCTGAAAAAAGAACTGGTTGCCCATCTGAAATGTACCATTACCGGCCTGACCTTCTGGGATCCGAGCTGTGAAGCAGAAGATCGTGGCGATAAATTCGTTCTGCGCAGTGCATATAGCAGTTGTGGCATGCAGGTTAGTGCCAGTATGATTAGTAATGAAGCCGTGGTTAATATTCTGAGCAGCAGTAGCCCGCAGCGCAAAAAAGTGCATTGCCTGAATATGGATAGTCTGAGCTTCCAGCTGGGTCTGTATCTGAGTCCGCACTTCCTGCAGGCCAGTAATACCATTGAACCGGGCCAGCAGAGCTTCGTTCAGGTGCGCGTTAGCCCGAGTGTGAGCGAATTCCTGCTGCAGCTGGATAGTTGCCATCTGGATCTGGGCCCGGAAGGTGGTACCGTTGAACTGATTCAGGGCCGCGCCGCCAAAGGTAATTGTGTGAGTCTGCTGAGTCCGAGCCCGGAAGGTGATCCGCGCTTCAGCTTCCTGCTGCACTTCTATACCGTGCCGATTCCGAAAACCGGTACCCTGAGCTGCACCGTGGCCCTGCGTCCGAAAACCGGCAGTCAGGATCAGGAAGTTCATCGTACCGTGTTCATGCGCCTGAATATTATTAGTCCGGATCTGAGTGGTTGTACCAGTAAAGGC
Available Sizes
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