Recombinant Murine GRO/KC/ CXCL1 (rMuKC/CXCL1)
KC coded by CXCL1 gene at chromosome 5 is approximately 63% identity to that of mouse MIP2. KC is also approximately 60% identical to the human GROs. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.
Product Specifications
CAS Number
9000-83-3
Endotoxin
Less than 1EU/μg of rMuKC/CXCL1 as determined by LAL method.
Purity
>97% by SDS-PAGE and HPLC analyses.
Bioactivity
Measured by its ability to chemoattract human CXCR2 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 3-15 ng/mL.
Reconstitution
Molecular Weight
Approximately 7.8kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.
Storage Conditions
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China
AA Sequence
APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK
Available Sizes
Frequently Asked Questions
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