Recombinant Human Interleukin-17F (rHuIL-17F)
Human IL-17F is synthesized as a 153 aa precursor with a 20 aa signal sequence and a 133 aa mature region. Like IL-17A, IL-17F contains one potential site for N-linked glycosylation. IL-17A and IL-17F share 50% aa sequence identity. IL17-F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17-F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Product Specifications
CAS Number
9000-83-3
Endotoxin
Less than 1EU/g of rHuIL-17F as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Bioactivity
Measured by its ability to induce IL-6 production by NHDF cells, it’s fully biologically active when compared to standard.
Reconstitution
Molecular Weight
A disulfide-linked homodimer of 30.1kDa, consisting of two 133 amino acid polypeptide chains.
Storage Conditions
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China
AA Sequence
MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Available Sizes
Frequently Asked Questions
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