Recombinant Human Stromal-Cell Derived Factor-1beta/CXCL12 (rHuSDF-1b/CXCL12)
Stromal-Cell Derived Factor-1 beta (SDF1β), also known as SCYB12, PBSF and CXCL12, is an 8.3 kDa, heparin-binding member of the CXC (or alpha) family of chemokines and signal through the CXCR4 receptor. SDF1α and β are reported to be monomers at neutral pH and physiologic ionic strength, On the cell surface, this may well facilitate SDF1 interaction with its two receptors, CXCR4 and syndecan4. Heparin sulfate is known to protect SDF1 from proteolysis, and CXCR4 exists constitutively as a dimer. Among its many functions, CXCL12 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis (12, 13) . It also enhances the survival of myeloid progenitor cells.
Product Specifications
CAS Number
9000-83-3
Endotoxin
Less than 1EU/μg of rHuSDF-1b/CXCL12 as determined by LAL method.
Purity
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM
Bioactivity
>95% by SDS-PAGE and HPLC analyses.
Reconstitution
Molecular Weight
Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.
Storage Conditions
Appearance
Measured by its ability to chemoattract human CXCR4 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 1-5 ng/mL.
Formulation
Sterile Filtered White lyophilized (freeze-dried) powder.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China
AA Sequence
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Available Sizes
Frequently Asked Questions
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