Tcl1 Recombinant Rabbit mAb
Product Specifications
Background
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]) .[supplied by OMIM, Jul 2010]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
TCL1
Swiss Prot
P56279
Reactivity
Human
Immunogen
A synthetic peptide of human Tcl1
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
14 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of extracts from Ramos cells at 1:1000.
Host or Source
Rabbit
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6387604-01 0.1 mL
NSF (Vesicle-fusing ATPase, N-ethylmaleimide-sensitive Fusion Protein, NEM-sensitive Fusion Protein, Vesicular-fusion Protein NSF) (FITC)
Ask
View Details MBS6387604-02 5x 0.1 mL
NSF (Vesicle-fusing ATPase, N-ethylmaleimide-sensitive Fusion Protein, NEM-sensitive Fusion Protein, Vesicular-fusion Protein NSF) (FITC)
Ask
View Details 250960 100 µg
RBMS2 (RNA Binding Motif, Single Stranded Interacting Protein 2, FLJ39093, FLJ40023, FLJ43262, SCR3)
Ask
View Details abx328946-01 50 µg
E3 Ubiquitin-Protein Ligase CBL Phospho-Tyr674 (CBL pY674) Antibody
Ask
View Details abx328946-02 100 µg
E3 Ubiquitin-Protein Ligase CBL Phospho-Tyr674 (CBL pY674) Antibody
Ask
View Details