HIRA Recombinant Rabbit mAb
Product Specifications
Background
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
TUP1; DGCR1; TUPLE1
Swiss Prot
P54198
Reactivity
Human
Immunogen
A synthetic peptide of human HIRA
Conjugation
Unconjugated
Applications
WB, ICC/IF, FC, IP
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
112 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of extracts from K562 cells using it at 1:1000.
Host or Source
Rabbit
Available Sizes
Curated Selection
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